Increased Reporting Accuracy of Alzheimer Disease Symptoms in Caribbean Hispanic Informants
نویسندگان
چکیده
منابع مشابه
Ultra-rare mutations in SRCAP segregate in Caribbean Hispanic families with Alzheimer disease
OBJECTIVE To identify rare coding variants segregating with late-onset Alzheimer disease (LOAD) in Caribbean Hispanic families. METHODS Whole-exome sequencing (WES) was completed in 110 individuals from 31 Caribbean Hispanic families without APOE ε4 homozygous carriers. Rare coding mutations segregating in families were subsequently genotyped in additional families and in an independent cohor...
متن کاملA founder mutation in presenilin 1 causing early-onset Alzheimer disease in unrelated Caribbean Hispanic families.
CONTEXT Genetic determinants of Alzheimer disease (AD) have not been comprehensively examined in Caribbean Hispanics, a population in the United States in whom the frequency of AD is higher compared with non-Hispanic whites. OBJECTIVE To identify variant alleles in genes related to familial early-onset AD among Caribbean Hispanics. DESIGN AND SETTING Family-based case series conducted in 19...
متن کاملEvidence of recessive Alzheimer disease loci in a Caribbean Hispanic data set: genome-wide survey of runs of homozygosity.
IMPORTANCE The search for novel Alzheimer disease (AD) genes or pathologic mutations within known AD loci is ongoing. The development of array technologies has helped to identify rare recessive mutations among long runs of homozygosity (ROHs), in which both parental alleles are identical. Caribbean Hispanics are known to have an elevated risk for AD and tend to have large families with evidence...
متن کاملIdentification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals.
OBJECTIVES To identify novel loci for late-onset Alzheimer disease (LOAD) in Caribbean Hispanic individuals and to replicate the findings in a publicly available data set from the National Institute on Aging Late-Onset Alzheimer's Disease Family Study. DESIGN Nested case-control genome-wide association study. SETTING The Washington Heights-Inwood Columbia Aging Project and the Estudio Famil...
متن کاملAPOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals.
BACKGROUND The APOE epsilon4 allele is a genetic risk factor for Alzheimer disease (AD), though the strength of the association varies by ethnic group. Polymorphisms in regulatory sequences of APOE have also been related to AD, but the effects are inconsistent across studies. METHODS We examined the association between AD and variants in 3 APOE promoters and in the promoter of the adjacent AP...
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ژورنال
عنوان ژورنال: Alzheimer Disease & Associated Disorders
سال: 2017
ISSN: 0893-0341
DOI: 10.1097/wad.0000000000000199